Cell Based & Biological Assay Applications

Real-Time, Label-Free Cell Analysis Across the Full Spectrum of Advanced Therapy Development and Production

Conventional cell analysis methods depend on fluorescent labels, manual workflows, and endpoint assays that create blind spots in some of the most critical phases of advanced therapy development. For researchers and biomanufacturers operating under tight timelines and increasingly stringent regulatory expectations, those blind spots translate directly into delayed decisions, inconsistent product quality, and increased risk.

LumaCyte’s Radiance® platform, powered by proprietary Laser Force Cytology™ (LFC) technology, addresses this gap with real-time, label-free single cell analysis built for the complexity of modern bioprocessing. Radiance® delivers unbiased, high-resolution cellular data across a broad range of applications, from viral vector infectivity quantification and cell vitality profiling to predictive stem cell and CAR-T potency characterization, PAT-compliant biomanufacturing analytics, and vaccine lot release. The result is a faster, more confident path from research through clinical production for the therapies that matter most.

Explore how Radiance® is applied across each application area below.

Speak to an Expert

Viral Vector Production

Radiance® enables rapid, label‑free quantification of viral infectivity across AAV, lentiviral, and other vector platforms, delivering the accuracy and throughput needed to reduce bottlenecks in process development, formulation, and lot release. Aligned with the global ISO 16921‑2 method, it supports standardized, high‑confidence viral vector characterization.

Cell Vitality & Viability

Unlike standard viability assays, Laser Force Cytology™ measures the physical and mechanical properties of individual cells in real time, detecting subtle shifts in cell state that precede visible loss of viability and directly influence manufacturing outcomes. This capability aligns with the global ISO 8934‑1 method, supporting standardized, high‑confidence assessment of cellular health in advanced bioprocessing.

Cell & Gene Therapy

Radiance® delivers real‑time, label‑free characterization of both autologous and allogeneic CAR‑T and stem cell populations, alongside precise single‑cell monitoring of AAV transfection and transduction. This functional insight strengthens potency assays, enhances process control, and supports regulatory confidence across cell and gene therapy programs.

Biomanufacturing & PAT Analytics

Radiance® supports next generation biomanufacturing workflows, delivering automated, real‑time monitoring of CMMs, CQAs, and CPP-sensitive in-process CQA surrogates. This supports FDA PAT framework requirements and improving process consistency from upstream culture through lot release.

Vaccines

LumaCyte enables rapid, reproducible viral infectivity testing across vaccine R&D, process development, formulation, and lot release, delivering precise single‑cell viral titers that strengthen cross‑lot and cross‑site comparability. These functional measurements support regulatory expectations for consistent, fit‑for‑purpose potency and neutralization assays.

Ready to Advance Your Program with Label-Free Analytics?

From process development to large-scale biopharmaceutical production, LumaCyte’s Radiance® platform is engineered for the analytical demands of advanced biologics and ATMP development. Whether your priority is improving process consistency, building regulatory confidence, accelerating lot release, or reducing the cost of batch failures, our application specialists are ready to show you exactly how Laser Force Cytology™ fits your workflow and program goals.

Speak to an Expert